Methods this international initiative had four phases. Derivation and validation of systemic lupus international. Slicc, systemic lupus international collaborating clinicsamerican college of rheumatology damage index. Slicc12, the new set of criteria established in 2012 to classify systemic lupus erythematosus, was recently examined for the first time on an adult european. The systemic lupus international collaborating clinics slicc 2012 criteria were more sensitive than the american college of rheumatology acr 1997 criteria in real. Sensitivity of the acr 1997 and of the slicc 2012 for clinically diagnosed sle as gold. In this initial validation testing, the slicc revised criteria had greater sensitivity but lower specificity than the 1997 acr classification criteria sensitivity of 97 versus 83 percent and specificity of 84 versus 96 percent, respectively. Objective the new systemic lupus international collaborating clinics slicc 2012 classification criteria aimed to improve the performance of systemic lupus erythematosus sle classification over the american college of rheumatology acr 1997 criteria. Therapeutic opportunities in systemic lupus erythematosus.
The slicc 2012 criteria set has been shown to be more sensitive than the acr 1997 criteria, to be applicable in childhoodonset sle and in those with early disease and to be usable in clinical practice 4. For the purpose of identifying patients in clinical studies, a person shall be said to have systemic lupus erythematosus if any 4 or more of the 11 criteria are present, serially or simultaneously, during any interval of observation. The diagnosis and treatment of systemic lupus erythematosus. Application of the 2012 systemic lupus international. For example, for the first time, the new criteria includes fever as a classification criterion, which receives 2 points if an infectious or other nonsle cause can be discounted. This study included children who were followed regularly in our lupus clinic with proved full house glomerular immune deposits nephritis and antinuclear ana, or anti. Their work included both a derivation and a validation of the new set of criteria as well as of acr97. The new 2019 sle european league against rheumatismamerican college of rheumatology eularacr classification criteria for systemic lupus erythematosus sle have been recently published. Slicc damage index score in systemic lupus erythematosus. In this brief report, we evaluated the performance of the proposed eularacr criteria in comparison with the fries diagnostic principle fdp, acr82, acr97 and slicc12, using two separate cohorts of patients with either potential or confirmed sle. Overall, the 1997 acr and the 2012 slicc criteria are similar for classifying sle in an uncontrolled real. Classification of systemic lupus erythematosus wiley online library. The slicc criteria classify more subjects with sle than acr criteria.
Slicc 12 criteria are more effectiveness than acr 97 score. Iraj salehiabari 2015, 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus. In crosssectional studies, elevated osteopontin opn levels have been proposed to reflect, andor precede, progressive organ damage and disease severity in systemic lupus erythematosus sle. Thus, slicc12 criteria were applied to confirmed sle cases in our regional sle register as well as to individuals. Performance of the 2012 systemic lupus international. Calculate is a nextgeneration clinical calculator and decision support tool freely available to the medical community. The decisive point of classification by the slicc 12 is the inclusion of an immunological criterion thus prohibiting the. Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder. Utility of the avise connective tissue disease test in. International collaborating clinics classification david eduardo saldvar gonzlez matrcula.
The slicc12 criteria contain additional clinical and. The slicc 2012 may allow patients to be classified as having sle earlier in the disease course. This is a retrospective cohort study of 94 sle patients attending rheumatology clinics in 2 local hospitals in kelantan, malaysia. A comparison of the american college of rheumatology acr. The study included a larger proportion of black and coloured patients than previous studies. Pdf 2015 acrslicc revised criteria for diagnosis of systemic. A recent study from cape town reports on 68 patients, with a median age of 12. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Access to society journal content varies across our titles. Four of the 11 criteria have to be fulfilled for a diagnosis of sle. This health tool is based on the 2012 classification created. Death data were prospectively collected or acquired through probabilistic linkage to vital statistics registries. The slicc12 ends the socalled double counting of photosensitive malar rash as two separate criteria as allowed with the acr97. Slicc criteria for sle slicc classification criteria for sle.
Study evaluates slicc12 classification criteria for lupus. The recent used diagnostic criteria widely used for sle is 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. Slicc is listed in the worlds largest and most authoritative dictionary database of abbreviations and acronyms the free dictionary. Systemic lupus erythematosus sle is an autoimmune disease that impacts many body systems, with a wide variety of signs and symptoms in each patient.
Systemic lupus erythematosus sle is an autoimmune disease that. Toward new criteria for systemic lupus erythematosusa standpoint. In order to create a more homogeneous patient group, the american college of rheumatology acr developed classification criteria for research purposes in 1972. To accomplish increased sensitivity and specificity figures, a combination of criteria sets for clinical sle studies should be considered, the authors recommended in the abstract. The criteria of the american college of rheumatology acr, first published in 1982 and revised in 1997, can be applied for the classification of sle 6, 7, e9. Slicc12 also failed in classification, as it misclassified more cases from the control group than either acr82, acr97 or fries. The patients were divided into 2 groups based on sdi score assigned by the attending physician, 0 without damage or. Looking for online definition of slicc or what slicc stands for. The diagnostic accuracies of the 2012 slicc criteria and. Autoimmune diseases and therapeutic approaches 2015 acr. The systemic lupus international collaborating clinics slicc recently validated. As shown in table 1, of the 5 patients with physician validated sle present in the cld who satisfied both the acr and slicc classification criteria, the acrbased ehr algorithm detected 79% 3985 as having sle, while the sliccbased algorithm detected 91% 4675. According to the slicc authors, the new clinical criteria improve the 1997 acr criteria in several ways.
Conclusions the slicc criteria classify more subjects with sle than acr criteria. Four antidsdna antibody assays in relation to systemic. A comparison of the proposed slicc criteria and the current 1997 acr criteria in the validation cohort showed a better performance of the slicc rule with higher sensitivity and fewer misclassifications of patients. Slicc classification criteria for systemic lupus erythematosus. Slicc classification criteria for sle current medical. We aimed, in a cohort of patients with recentonset sle, to determine whether raised serum opn levels precede damage andor are associated with disease activity or certain. Use of slicc criteria in a large, diverse lupus registry enables sle. In the immediate clinical trial setting, the sdi is also an important stratification factor to bear in mind as it is so strongly.
Results of 3575 subjects classified with sle under at least one system, 3312 92. The hookup men will then place the apex fitting into the aircraft cargo hook and ensure that the hook is properly closed and locked. Diagnostic criteria for systemic lupus erythematosus. The systemic lupus international collaborating clinics. The systemic lupus international collaborating clinics slicc damage index. This systemic lupus diagnostic criteria slicc calculator helps the classification and diagnosis of sle based on clinical and immunological criteria. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and is especially. Pdf 2015 acrslicc revised criteria for diagnosis of. Slicc criteria for sle slicc classification criteria for. In 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc12 to classify systemic lupus erythematosus sle. The 2012 revised slicc criteria for classification of. If a patient meets at least four criteria, lupus can be diagnosed with 95%.
Systemic lupus diagnostic criteria slicc calculator. The slicc12 has a broader scope than the acr97, with 18 items in the criteria set compared with 11 for the acr. Estimate 10year risk for atherosclerotic cardiovascular disease revised cardiac risk index lee criteria. It was noteworthy that 22 lupus nephritis patients failed to meet four of the acr criteria. The slicc criteria were validated by analysis of 690 patients with sle or other rheumatic diseases. The hookup team will be in position at the load when the helicopter arrives. Slicc network, devoted to clinical research in sle, presented a new set of classification criteria in 2012 slicc12 based on the evaluation of almost 1,400 patient scenarios 10. Use of slicc criteria in a large, diverse lupus registry. Reilly et al 2014 in buckinghamshire, this debate was discussed at the april 2015 speech and language therapy service meeting. In the text below the form there is information on the slicc, along with instructions on how to interpret the criteria that is present. Metabolic syndrome in argentinean patients with systemic.
Newly diagnosed sle patients with disease duration less than 6 months were excluded. New classification system for sle may aid earlier diagnosis. Iraj salehiabari 2015, 2015 acrslicc revised criteria for diagnosis of systemic lupus erythematosus. However, the slicc 2012 criteria need further external validation. A list of items considered to reflect damage in sle was generated through a nominal group from the systemic lupus international collaborating clin ics slicc and the american college of rheumatology diagnostic and therapeutic criteria committee. The 2012 slicc classification criteria for sle classify a patient as having sle if a the patient satisfies four of the criteria, including at least one clinical criterion and one immunologic criterion or. Pdf performance of the new slicc classification criteria.
The preliminary criteria including 14 items were effective in excluding normal patients in the population from which it was derived. Our objective was to compare the sensitivity for sle. The slicc criteria were validated by analysis of 690. The present study is the first to evaluate the performance of slicc12 in an adult european study population. Slicc criteria are very complexextended criteria and it can be used when the acr criteria cannot classify sle. Moreover, lecell test were often unavailable for these patients, thus high titers of antinuclear antibodies were also utilized as a criteria for validation. The slicc criteria showed better sensitivity p lupus nephritis as the sole clinical criterion in the presence of ana or antidsdna antibodies. New sle classification criteria reset disease definition.
Osteopontin and disease activity in patients with recent. Sling load inspector certification course flashcards quizlet. Pdf on apr 20, 2015, iraj salehi abari and others published 2015 acrslicc revised criteria for diagnosis of systemic. Fever has recently been identified as a marker of earlystage sle in at least some patients, and its addition to the classification criteria adds a new dimension to. To address these problems, the systemic lupus international collaborating clinics slicc research group recently proposed a new classification criteria set slicc 2012 5. This has evolved from the american rheumatism association 1982 criteria and the acr 1997 criteria to the slicc 2012 criteria. Systemic lupus erythematosus diagnosis and management. A total of 178 patients meeting the acr82 andor the slicc12 were included in the study 2,3. Pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. A total of 155 patients fulfilled the acr82 87%, 173 fulfilled the slicc12 97%, and 150 patients fulfilled both criteria.
The proposed classification is based on 11 criteria. Performance of the proposed acreular classification. Sle is an autoimmune condition that can damage multiple organ systems. The sensitivity and specificity of the acr criteria were 76. What are eularacr diagnostic criteria for systemic lupus. However, it performed less well in patients during the early stage of their disease. Collaboration of the systemic lupus international collaborating clinics slicc and the canadian network for improved outcomes in systemic lupus canios investigator groups us, canada, england, scotland, iceland, sweden, south korea. Slicc criteria yielded higher sensitivity 97% versus 83% but lower specificity 84% versus 96% than acr 1997 criteria in the original validation set 7.
Reprinted with permission from bertsias gk, salmon je, boumpas dt. This was the most frequent cause for losing sle classification in the. Criteria are cumulative and need not be present concurrently. The slicc 2012 criteria were more sensitive than the acr 1997 criteria in real. Slicc 12 criteria are more effectiveness than acr 97 score about.452 243 193 1209 822 1446 554 268 1211 55 174 1249 411 145 108 1140 973 290 1445 427 840 926 237 603 283 1134 61 1432 657 87 108 485 111 448 216 222